FLORHAM PARK, N.J. — Sam Darnold is sick and sidelined — likely for several weeks.

New York Jets coach Adam Gase announced Thursday the second-year quarterback has mononucleosis and will miss at least the team's game against the Cleveland Browns on Monday night.

Trevor Siemian will start in Darnold's place, and could be the starter moving forward until Darnold recovers. The Jets have a game at New England in Week 3 before they have a bye-week break, and then games at Philadelphia, at home against Dallas and New England before a road game at Jacksonville on Oct. 27 to cap a rough opening stretch.

When a reporter pointed out that mono usually take several weeks from which to heal, Gase nodded.

"Oh, I'm aware," Gase said. "Good thing we've got the early bye week."

Darnold was sent home by the team Wednesday with what Gase said was "strep throat or something." Team doctors later told Gase that antibiotics weren't working as quickly as expected, leading to the diagnosis.

"He's going through some of these tests to kind of see where he's at with all this," Gase said. "I know he's out this week. Then, past that, I'll have more information as we go."

Gase said Luke Falk will be promoted from the practice squad to serve as Siemian's backup. The Jets could also look to sign an experienced quarterback for depth.

But, for now — and probably the next handful of games — it will be Siemian leading New York's offense.

Siemian was signed as a free agent in the offseason after spending last season with Minnesota. The 27-year-old quarterback played in Denver his first three NFL seasons, and is 13-11 as a starter. He has thrown 5,686 yards and 30 touchdowns with 24 interceptions.

"I feel pretty comfortable with what we're doing," Siemian said. "Excited to compete, for sure."

Gase said the Jets' approach on offense won't change much with Siemian taking over for Darnold.

"That's why Trevor's here," the coach said. "We signed Trevor specifically because he has 24 starts over his career with a winning record, has a lot of experience, has been on winning ballclubs. He has the respect of the locker room.

Nearly overshadowed in the stunning news about the quarterback was Gase announcing that running back Le'Veon Bell would be among the players sitting out of practice because of a sore shoulder.

Bell was solid in his Jets debut last Sunday, his first game in nearly 20 months after sitting out in a contract dispute with Pittsburgh. ESPN reported that an MRI revealed no damage to Bell's shoulder, and he is likely to play against the Browns.

"I'm waiting to find out the extent of this," Gase said earlier in the day. "This could be just soreness. We don't think it's anything worse than that, but we're just kind of probably being a little extra cautious."

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