The Tampa Bay Lightning's Steven Stamkos, the New Jersey Devils' Taylor Hall and the Calgary Flames' Johnny Gaudreau will all miss time with significant injuries.
Stamkos and Hall each have meniscus tears in their knees that will sideline both indefinitely, while Gaudreau requires surgery on a broken finger.
Lightning general manager Steve Yzerman announced Stamkos' diagnosis Wednesday after Tampa Bay's captain returned home for further evaluation of the injury the two-time NHL scoring champion suffered Tuesday night in a 4-3 victory over the Detroit Red Wings.
"We are in the process of evaluating options for repair and rehabilitation and will release more information as it becomes available," Yzerman said.
Stamkos, who last summer re-signed with the team that drafted him No. 1 overall in 2008 rather than testing free agency, scored his ninth goal against the Red Wings and leads the NHL with 20 points in 17 games.
The six-time All-Star center grabbed the back of his knee and limped off the ice to the dressing room after colliding with Detroit's Gustav Nyquist along the boards.
It's the third significant injury Stamkos has had over the past three years.
After helping Tampa Bay reach the 2015 Stanley Cup Final, he missed all but one game of last season's playoffs after undergoing surgery to remove a blood clot discovered near his collarbone. He also missed significant playing time three years ago, when he broke his right leg against Boston in November 2013 and was sidelined 45 games.
The 26-year-old cited loyalty, respect and the potential to win for years as major reasons for re-signing with the Lightning rather than testing free agency, where he likely would have commanded much more than the $68 million he's scheduled to earn over the next eight seasons.
The Devils announced Wednesday that Hall had a torn meniscus repaired in a procedure performed by team physician Dr. Michael Shindle and Dr. Jonathan Glashow, the club's chief medical officer. He will be sidelined up to a month and has been placed in injured reserve.
Hall, who was acquired from the Edmonton Oilers in an offseason deal for defenseman Adam Larsson, had five goals and seven assists in 14 games. His 12 points were tied for the team lead.
The No. 1 overall pick in the 2010 draft, Hall did not play in the Devils' game at Dallas on Tuesday night.
Gaudreau was scheduled to undergo surgery Wednesday for a fractured finger.
Gaudreau suffered the injury in Calgary's 1-0 win Tuesday over the Minnesota Wild. The team said a timeline for his return will be provided in the coming days.
"It's his finger so it can be four (weeks), it can be six, you don't know," Flames coach Glen Gulutzan said.
"For me, I'm just preparing for the worst-case scenario and that's how it goes. But we won't know anything on this injury until we hear from the doctors. It could be less, it could be more."
Gaudreau appeared to suffer the injury while taking a slash to the hand against Minnesota.
"The NHL has tried to crack down on that stuff," Gulutzan said. "What we did last night was we addressed it with the officials, after the second period. There were a few whacks there that Johnny had to go off for. But the third whack got him. But we addressed it."
The 23-year-old native of Salem, N.J., has 11 points (five goals, six assists) in 17 games this season.